About This Project
Infection of the clear layer of the front of the eye, the cornea, leads to scarring and vision loss exacerbated by robust inflammation. Understanding of some of these mechanisms has been gained from animal and cell based studies, but the specialized tools to verify and look for novel pathways in patients have slowly been developed. The eye is an easily accessible tissue, however the interface with the outside environment and the small volume samples that can be collected pose difficulties. Innovative technologies have allowed the team to combine specialized techniques of small sample processing with powerful analytical platforms to maximise this information. In this study both tear and serum molecules will be investigated as potential prognostic biomarkers and novel inflammatory pathway predictors in corneal infection. Better understanding of the inflammatory mechanisms in corneal infection is key to limiting vision loss and improving quality of life.